In addition, sharing these data without approval from the Manitoba Health Information Privacy Committee and Health Research Ethics Board of the University of Manitoba is against existing data management policy. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: Our study data contain patient's private information. Received: SeptemAccepted: NovemPublished: December 7, 2017Ĭopyright: © 2017 Yang et al. PLoS ONE 12(12):Įditor: Qing Wu, University of Nevada Las Vegas, UNITED STATES ICD-coded obesity predicted incident MOF, though it had low sensitivity and reclassified MOF risk slightly less well than measured obesity.Ĭitation: Yang S, Lix LM, Yan L, Hinds AM, Leslie WD (2017) International Classification of Diseases (ICD)-coded obesity predicts risk of incident osteoporotic fracture. Although the area under the receiver operating characteristic curve (AUROC) estimates for incident MOF were not significantly different for ICD-coded obesity versus measured obesity (0.648 for ICD-coded obesity versus 0.650 for measured obesity P = 0.056 for AUROC difference), the category-free net reclassification index for ICD-coded obesity versus measured obesity was -0.08 (95% CI: -0.11, -0.06) for predicting incident MOF. ICD-coded obesity (adjusted hazard ratio 0.83 95% CI: 0.70, 0.99) and measured obesity (adjusted HR 0.83 95% CI: 0.78, 0.88) were associated with decreased MOF risk. The sensitivity, specificity and positive predictive value for ICD-coded obesity using measured obesity as the reference were 0.11 (95% confidence interval : 0.10, 0.11), 0.99 (95% CI: 0.99, 0.99) and 0.79 (95% CI: 0.77, 0.81), respectively. Average cohort age was 66.3 years and 90.3% were female. Hospital and physician ICD codes were used to ascertain ICD-coded obesity and incident MOF. Body mass index (BMI) ≥30 kg/m 2 was used to define measured obesity. In this historical cohort study (2001–2015), we selected 61,854 individuals aged 50 years and older from the Manitoba Bone Mineral Density Database, Canada. We tested the utility of ICD-coded obesity versus measured obesity for predicting incident major osteoporotic fracture (MOF), after adjusting for covariates (i.e., age and sex). There has been limited research about the predictive value of ICD-coded obesity for major chronic conditions at the population level. International Classification of Diseases (ICD) codes have been used to ascertain individuals who are obese.
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